GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1577917 | 1 | rs12215037 | chr6:86727631 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -18.12 | 3.43E-64 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12215903 | chr6:86675028 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -17.54 | 1.09E-60 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12215913 | chr6:55996995 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.82 | 1.48E-11 | Psychosis (atypical) |
| BRCA | cis | rs12216499 | 1 | rs12215936 | chr6:159371324 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.71 | 0.000216 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs1577917 | 1 | rs12216203 | chr6:86675301 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -18.5 | 1.83E-66 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12216314 | chr6:55997673 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.82 | 1.48E-11 | Psychosis (atypical) |
| BRCA | cis | rs1577917 | 1 | rs12216328 | chr6:86703418 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -18.93 | 4.05E-69 | Response to antipsychotic treatment |
| BRCA | cis | rs12216499 | 1 | rs12216499 | chr6:159368524 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.71 | 0.000216 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs11190604 | 1 | rs12219158 | chr10:102302923 | SEC31B | chr10:102246403-102289636:- | -0.29 | -10.82 | 6.07E-26 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs12219789 | chr10:102213778 | SEC31B | chr10:102246403-102289636:- | -0.28 | -10.23 | 1.66E-23 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11185790 | 1 | rs12219790 | chr10:91375491 | FLJ37201 | chr10:91451057-91457685:- | -0.17 | -3.76 | 0.000178 | Metabolic traits |
| BRCA | cis | rs12220777 | 1 | rs12220777 | chr10:81788104 | LOC219347 | chr10:81805991-81838949:- | -0.44 | -7.72 | 2.58E-14 | Chronic obstructive pulmonary disease-related biomarkers |
| BRCA | cis | rs10205487 | 1 | rs12232914 | chr2:70117176 | ANXA4 | chr2:69969127-70053594:+ | -0.13 | -3.85 | 0.000124 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs12237653 | 1 | rs12237653 | chr9:2551654 | FLJ35024 | chr9:2422702-2622373:- | 0.37 | 8.22 | 5.98E-16 | Gambling |
| BRCA | cis | rs7084921 | 1 | rs12243096 | chr10:101812302 | CWF19L1 | chr10:101992055-102027437:- | 0.13 | 3.67 | 0.000253 | Bone mineral density |